Can menopause be predicted by using multiple AMH blood measurements?

If you are a women who has had fertility tests or treatment, it is likely that you may have had an Anti Mullerian Hormone blood test (AMH) An AMH blood test is often used by fertility clinicians as a predictor of a women's ovarian reserve and a women's possible response to fertility treatment. In women AMH is produced in the ovaries by the granulosa cells of antra follicles with levels peaking in women around the age of 25. Could this type of blood test also be used as a predictor of menopause?


The average age of menopause is around the age of 51, the peri menopause typically starts around 6-8 years prior to menopause. It is thought that during the peri menopause the number of ovarian follicles decreases steeply. Some studies have suggested that AMH levels are very low or undetectable around 5 years before menopause.


A recent study attempted to answer this question using data and blood results from over 2434 women. They were followed up every 5 years with a blood test and medical questionnaire which were then analysed by researchers. This study was limited we could ask the question was 5 years to long in between AMH levels? also the assessment of age at menopause was determined using a questionnaire, it could be argued that this could be misinterpreted


It is important to know that a prediction of menopause does not correspond with fertility duration and predicting and individualising menopause is still in need of improvement. The prediction of menopause does not necessarily correspond to the prediction of fertility duration, which ultimately is the outcome of interest in many women. Similar studies have not found an association of AMH levels with time to pregnancy and cumulative conception rates in women aged 30 - 44.


In conclusion, the study found the measurement of multiple AMH levels over time does not improve the prediction of individual risk of menopause occurrence compared with a single AMH level. More research and study is needed on this interesting subject.


Reference

De Kat. A. et al (2019) Can Menopause prediction be improved with multiple AMH results? The Journal of Clinical Endocrinology and Metabolism 104 (11) Pg 5024-5031






56 views0 comments